So, why is dexmedetomidine only approved for use for

So, why is dexmedetomidine only approved for use for <24 hours?

Dexmedetomidine is centrally-acting highly-selective a2-receptor agonist that is approved by the Food and Drug Administration (FDA) for sedation in the ICU for less than 24 hours in 19991.  As dexmedetomidine is more selective towards the 2A subtype of the receptor, it causes more sedation and analgesia than the other commonly used a2-receptor agonist clonidine5.  However, [...]
So, why is dexmedetomidine only approved for use for

So, why is dexmedetomidine only approved for use for

Dexmedetomidine is centrally-acting highly-selective a2-receptor agonist that is approved by the Food and Drug Administration (FDA) for sedation in the ICU for less than 24 hours in 19991.  As dexmedetomidine is more selective towards the 2A subtype of the receptor, it causes more sedation and analgesia than the other commonly used a2-receptor agonist clonidine5.  However, [...]
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